Association between gingival crevicular fluid prostaglandin E ₂ level and preterm low birth weight.

Research paper by Fouzia F Tarannum, Mohamed M Faizuddin

Indexed on: 31 Jul '12Published on: 31 Jul '12Published in: Indian journal of dental research : official publication of Indian Society for Dental Research


Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E ₂ (PGE ₂), may pose a threat to the fetal-placental unit and cause preterm delivery.This study was conducted to estimate the PGE 2 levels in gingival crevicular fluid (GCF) and to explore the association between GCF-PGE ₂ levels and preterm low birth weight (PLBW).Twenty-two pregnant patients were selected for the study. GCF samples were collected from these patients before delivery and again at 1 month after delivery. PGE ₂ level was estimated using a commercially available ELISA kit (Neogen).The mean GCF-PGE ₂ level was 5.8 ng/ml before parturition and 5.5 ng/ml after parturition, but the difference was not statistically significant. There was negative correlation between PGE ₂ levels and gestational age at birth.The study provides weak evidence that there is correlation between GCF-PGE ₂ levels and birth outcome. Further clinical trials with large samples are required to confirm the association between GCF-PGE ₂ levels and PLBW.