Assessment of the link between Vitamin D receptor TaqI gene polymorphism and periodontitis: a meta-analysis in a Chinese population.

Research paper by X W XW Ji, Y Y Wang, C C Cao, L J LJ Zhong

Indexed on: 04 Nov '16Published on: 04 Nov '16Published in: Genetics and molecular research : GMR


Although a number of studies have been conducted to determine the association between vitamin D receptor (VDR) TaqI polymorphism and periodontitis in the Chinese population, this association remains elusive. To assess the influence of VDR TaqI polymorphism on the risk of periodontitis, a meta-analysis was performed in a Chinese population. Relevant studies were identified using the databases PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, through January 2016. Pooled odds ratios and 95% confidence intervals were used to assess the strength of the associations. This meta-analysis identified 9 studies, which included 1014 periodontitis cases and 907 controls. In both overall and subgroup analyses, VDR TaqI polymorphism was not associated with the risk of periodontitis. Cumulative analysis also suggested a lack of association between VDR TaqI polymorphism and the risk of periodontitis in the Chinese population. In conclusion, our meta-analysis showed that VDR TaqI polymorphism is not associated with the risk of periodontitis in the Chinese population. Further studies in other ethnic groups are required for definite conclusions.