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Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242.

Research paper by Ze'en Z Xiao, Huarong H Huang, Changlun C Shao, Xuekui X Xia, Lin L Ma, Xishan X Huang, Yongjun Y Lu, Yongcheng Y Lin, Yuhua Y Long, Zhigang Z She

Indexed on: 07 May '13Published on: 07 May '13Published in: Organic Letters



Abstract

Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC50 values of 2.3 and 3.0 μM, respectively.