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Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia.

Research paper by Michael L ML Ciccolo, Jonathan J Bernstein, Juan C JC Collazos, Ruben J RJ Acherman, Humberto H Restrepo, James M JM Winters, Justin J Krueger, William N WN Evans

Indexed on: 22 Aug '08Published on: 22 Aug '08Published in: Congenital Heart Disease



Abstract

Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy. Anticoagulation in pediatric patients with HIT is challenging as there are no approved heparin substitutes. We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of HIT.