Arachidonic acid metabolites: Effects on inflammation of fetal rabbit excisional wounds

Research paper by Michael J. Morykwas, Elizabeth A. Duell, Debby A. Jennings, M. Stephen Ledbetter, Wain L. White, Louis C. Argenta

Indexed on: 01 Jun '92Published on: 01 Jun '92Published in: Inflammation


Uncovered fetal rabbit excisional wounds do not exhibit any classic signs of healing; wounds covered with an impermeable cover do contract, reepithelialize, and exhibit inflammation. Prostaglandin E2 (PGE2) is elevated in amniotic fluid, acting as an immunosuppressant at the maternal-fetal interface. Full-thickness excisional wounds were made on 25-day gestational age rabbit fetuses. Half the wounds were covered with an impermeable cover. Tissue from covered, uncovered, and nonwounded fetuses was examined 72 h after wounding for arachidonic acid metabolites. Uncovered wounds had significantly (P≤0.05) elevated levels of PGE2, PGE2α, and 12-HETE versus covered wounds and control tissue. Covered wounds had significantly elevated levels of 15-HETE compared to uncovered and control tissue. The elevated PGE2 in uncovered wounds may act as a fetal immunosuppressant; covered wounds (lower PGE2) developed cellular inflammation. Further investigations of these interactions may permit modulation of adult inflammation.