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Application of Solid-State NMR to Reveal Structural Differences in Cefazolin Sodium Pentahydrate From Different Manufacturing Processes.

Research paper by Ye Y Tian, Wei D WD Wang, Wen-Bo WB Zou, Jian-Qin JQ Qian, Chang-Qin CQ Hu

Indexed on: 26 Apr '18Published on: 26 Apr '18Published in: Frontiers in chemistry



Abstract

Solid-state Nuclear magnetic resonance, thermogravimetric analysis, X-ray diffraction, and Fourier-transform infrared spectroscopy were combined with theoretical calculation to investigate different crystal packings of α-cefazolin sodium obtained from three different vendors and conformational polymorphism was identified to exist in α-cefazolin sodium. Marginal differences observed among cefazolin sodium pentahydrate 1, 2, and 3 were speculated as being caused by the proportion of conformation .