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Apoptotic effect of atorvastatin in glioblastoma spheroids tumor cultured in fibrin gel

Research paper by Neda Bayat, Somayeh Ebrahimi-Barough, Abbas Norouzi-Javidan, Hooshang Saberi, Roksana Tajerian, Mohammad Mehdi Mokhtari Ardakan, Sadegh Shirian, Arman Ai, Jafar Ai

Indexed on: 09 Nov '16Published on: 08 Nov '16Published in: Biomedicine & Pharmacotherapy



Abstract

Glioblastoma multiform (GBM) is one of the most common and highly aggressive primary brain tumors that thought to be of glial cells origin. The new available therapy for glioblastoma is based on better understanding of molecular malignant progression in this tumor. It is better to identify key molecular targets stimulating signaling pathways that lead to initiation of apoptosis for treatment of glioblastoma. Tumorigenesis broadly is controlled by tumor microenvironment and design of best biomimetic culture systems dependency on these conditions allow for in vitro and in vivo tumor modeling for studies of cancer cells behavior to drugs. We engineered three-dimensional (3D) human tumor models using U87 glioma cells in fibrin gel that mimic microenvironmental feature of glioblastoma in vivo. In this study, atorvastatin was used as a kind of statins for induction of apoptosis, and inhibition of migration and invasion in glioma cells.

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