Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity.

Research paper by Daniel D Mitchell, Guy J GJ Clarkson, David J DJ Fox, Rebecca A RA Vipond, Peter P Scott, Matthew I MI Gibson

Indexed on: 18 Jul '17Published on: 18 Jul '17Published in: Journal of the American Chemical Society


Antifreeze proteins are produced by extremophile species to control ice formation and growth, and have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically-pure, amphipathic metallohelicies inhibited ice growth at just 20 μM. Structure-property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.