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Antidotal effects of thymoquinone against neurotoxic agents.

Research paper by Ali Rajabpour AR Sanati, Tahereh T Farkhondeh, Saeed S Samarghandian

Indexed on: 20 Nov '19Published on: 01 Aug '18Published in: Interdisciplinary toxicology



Abstract

Several plants which contain the active component thymoquinone (TQ) have been traditionally used in herbal medicine to treat various diseases. Several studies indicated the protective effects of TQ against neurotoxic agents. The present study was aimed to highlight the protective effects of TQ against neurotoxic agents. For this reason, the literature from 1998 to 2017 regarding the protective effects of TQ against neurotoxic agents and their involvement mechanisms has been studied. The present review suggests the protective effects of TQ against neurotoxic agents in experimental models. More clinical trial studies are however needed to confirm the antidotal effects of TQ in human intoxication. Copyright © 2018 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.