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Antidiarrheal activity of Capparis zeylanica leaf extracts.

Research paper by Karanayil R KR Sini, Barij N BN Sinha, Aiyolu A Rajasekaran

Indexed on: 16 Dec '11Published on: 16 Dec '11Published in: Journal of advanced pharmaceutical technology & research



Abstract

The antidiarrheal activity of the methanolic extract of the leaves of Capparis zeylanica (Capparidaceae) was investigated by castor oil-induced diarrhea and small intestine transit method on mice. Like loperamide (3 mg/kg body weight), C. zeylanica methanolic extract (100,150,200 mg/kg body weight) produced a significant decrease in the severity of diarrhea. The percentage protection in extract-treated animals showing diarrhea was compared with castor oil-treated and loperamide-treated animals. The activity was found to be dose-dependant. Its effect when evaluated on intestinal transit produced a decrease in intestinal transit (75.97%).The results revealed that the methanolic extract significantly reduced diarrhea in mice with reduction in weight of stools.