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Antibacterial Activity Evaluation of Silver Nanoparticles Entrapped in Silica Matrix Functionalized with Antibiotics

Research paper by Madalina Tudose, Daniela C. Culita, Cornel Munteanu, Jeanina Pandele, Elena Hristea, Petre Ionita, Irina Zarafu, Mariana Carmen Chifiriuc

Indexed on: 05 Feb '15Published on: 05 Feb '15Published in: Journal of Inorganic and Organometallic Polymers and Materials



Abstract

This study reports the synthesis of silver nanoparticles (Ag NPs) by the sodium borohydride reduction method and their embedding in a silica shell functionalized with several antibiotics (ampicillin, penicillin G and isoniazide). The characterization of the novel materials was made by UV–visible absorption spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy, dynamic light scattering and thermal analysis. TEM micrographs revealed the formation of spherical nanoparticles with size ranging between 20 and 50 nm. The Ag NPs embedded in the silica network exhibited a good antimicrobial efficiency, comparable or even superior to that of antibiotic-containing formulations. This is the first report regarding the synergic antimicrobial effect of Ag NPs embedded in silica and ampicillin, both against planktonic cells and biofilms formed by P. aeruginosa and S. aureus, two of the most fearful resistant bugs. These results are demonstrating the great potential of these nanocomposites to be used in developing novel antimicrobial agents or improving the existent ones, by increasing their efficiency, extending their spectrum of activity and decreasing the probability to select resistance, by simultaneously targeting multiple targets in the microbial cells.

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