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Analysis of Numerous Androgen Disruptors in Fish by Gas Chromatography Tandem Mass Spectrometry.

Research paper by Shaoying S Liu, Tianbin T Bian, Huali H He, Xihui X Huang, Quan Q Jin, Shuting S Wang, Guonian G Zhu

Indexed on: 25 Jan '17Published on: 25 Jan '17Published in: Journal of AOAC International



Abstract

An improved analytical method was developed for the simultaneous quantification of numerous androgen disruptors-vinclozolin, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes, chlordane, heptachlor, dieldrin, endrin, and aldrin-in fish, followed by GC with tandem MS (MS/MS). Extraction, cleanup, and MS/MS parameters of analytes were optimized. The LOQs of the analytes ranged from 0.3 to 3.7 μg/kg. Reasonable recoveries (73.7-119.2%) were demonstrated at different spike levels with RSDs lower than 12.2%. This method was applied for the analysis of the target analytes in fish samples sold in Hangzhou, China, and DDTs were found to be the predominant contaminants in fish samples.