An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate.

Research paper by Abdelrahman S AS Mayhoub, Evgeny E Kiselev, Mark M Cushman

Indexed on: 20 Sep '11Published on: 20 Sep '11Published in: Tetrahedron Letters


Aryl thioamides undergo a very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency.