An improved synthesis of alpha-carbolines under microwave irradiation.

Research paper by Patricia P Vera-Luque, Ramón R Alajarín, Julio J Alvarez-Builla, Juan J JJ Vaquero

Indexed on: 27 Jan '06Published on: 27 Jan '06Published in: Organic Letters


[reaction: see text]. Alpha-carbolines are interesting core structures for designing DNA-interacting small molecules. However, these compounds are not commercially available and their synthetic methods are low yielding or time consuming. The shortest synthetic route, the modified Graebe-Ullmann reaction, has been optimized by using microwave heating in four different types of apparatus to give shorter reaction times and enhanced yields. Optimized conditions enabled the preparation of a small library of alpha-carbolines.