An extremely active catalyst for the Negishi cross-coupling reaction.

Research paper by Jacqueline E JE Milne, Stephen L SL Buchwald

Indexed on: 08 Oct '04Published on: 08 Oct '04Published in: Journal of the American Chemical Society


A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.