An approach for the synthesis of nakamuric acid.

Research paper by Xiaolei X Wang, Chuo C Chen

Indexed on: 20 May '15Published on: 20 May '15Published in: Tetrahedron


The biosynthesis of dimeric pyrrole-imidazole alkaloids is likely mediated by enzyme-catalyzed reversible single-electron transfer (SET) cycloaddition. We now show that Ir(ppy)3 can promote SET-mediated formal [2+2] and [4+2] cycloaddition reactions of pyrrole-imidazole alkaloids-related substrates under photolytic conditions. This biomimetic approach is useful for the construction of the core skeleton of nakamuric acid and sceptrin.