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Amyloid beta 1-42 in cerebrospinal fluid is associated with cognitive plasticity.

Research paper by Ingo I Uttner, Niklas N Schurig, Christine A F CA von Arnim, Christian C Lange-Asschenfeldt, Johannes J Brettschneider, Matthias W MW Riepe, Hayrettin H Tumani

Indexed on: 31 May '11Published on: 31 May '11Published in: Psychiatry Research



Abstract

Cerebrospinal fluid (CSF) total tau-protein (t-tau) and amyloid-beta 1-42 (Abeta(1-42)) have been increasingly included in the diagnostic process of Alzheimer's disease (AD). We aimed to analyze whether these CSF biomarkers correlate with cognitive plasticity as measured by a dynamic recognition test strategy. We assessed 29 elderly individuals (15 with incipient and 14 without AD) from an outpatient memory clinic at a university hospital by a Testing-the-Limits (TtL) based recognition paradigm consisting of a pre-test (baseline) and two post-test conditions with an interposed encoding instruction. We identified a negative association between Abeta(1-42) and the two post-test failure rates, but not with that of the pre-test. Also, none of the standard tests correlates with Abeta 42-1 level. T-tau does not correlate with recognition performance. Our results suggest that Abeta(1-42) could be useful as a state marker for cognitive plasticity.