AIE-active self-assemblies from a catalyst-free thiol-yne click reaction and their utilization for biological imaging

Research paper by Ruming Jiang, Meng Cao; Meiying Liu; Liangji Liu; Qiang Huang; Hongye Huang; Yuanqing Wen; Qian-yong Cao; Xiaoyong Zhang; Yen Wei

Indexed on: 30 Jun '18Published on: 21 Jun '18Published in: Materials Science and Engineering: C


Publication date: 1 November 2018 Source:Materials Science and Engineering: C, Volume 92 Author(s): Ruming Jiang, Meng Cao, Meiying Liu, Liangji Liu, Qiang Huang, Hongye Huang, Yuanqing Wen, Qian-yong Cao, Xiaoyong Zhang, Yen Wei Aggregation-induced emission (AIE) should be the most interest fluorescent phenomenon over the past few decades. The luminescence polymeric nanoparticles (LPNs) with AIE characteristic have attracted great research attention for biological imaging and many other biomedical applications owing to their good biocompatibility and negative toxicity. However, the preparation of LPNs with desirable optical properties using traditional organic dyes still remains a great challenge for the aggregation-caused quenching (ACQ) effect and aggregation of hydrophobic dyes in the core of LPNs. In this work, we reported a novel and simple method for fabrication of biodegradable AIE-active LPNs via the combination of condensation and click reactions. For preparation of these AIE-active LPNs, the thiol groups-containing hydrophilic copolymers (PEG-MA) were first synthesized through the condensation reaction between polyethylene glycol and mercaptosuccinic acid. The PEG-MA copolymers were further reacted with AIE dye PhE-OE through a catalyst-free thiol-yne click reaction. These obtained PEG-MA-PhE LPNs were fully characterized by a number of characterization techniques. All the results confirmed that PEG-MA-PhE LPNs possess excellent compatibility, intense red luminescence, great photostability and high water dispersibility. These features make PEG-MA-PhE LPNs promising candidates for various biomedical applications. Graphical abstract

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