Adrenergic regulation of contractile activity in the smooth muscle of umbilical vessels

Research paper by V. A. Orchakov, I. A. Vladimirova, M. P. Shuba, V. S. Artamonov

Indexed on: 01 Jul '89Published on: 01 Jul '89Published in: Neurophysiology


A study was made of contractile activity produced in isolated muscle strips from human umbilical vessels by adrenomimetics and adrenoblockers. Activation of β-as well as α-adrenoceptors was found to cause contraction in the smooth muscle of the umbilical arteries and veins — a different effect from that occurring in other vessels. Selective shut-down of α- or β-receptors under the action of phentolamine and obsidane would indicate that activation of α- and β-adrenoceptors are responsible for mainly phasic and tonic components (respectively) of smooth muscle contraction in the umbilical vein. Obsidane was also found to inhibit the tonic component of contraction induced by oxytocin. In the smooth muscle cells of the umbilical artery, α- and β-receptors produce nonselective inhibition of noradrenaline-induced contraction, which obviously indicates limited differentiation in the adrenoceptors of this vessel. In view of the experimental findings obtained, application of obsidane either separately or in combination with oxytocin might be recommended for obstetrical use.