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Acute clearance of human metapneumovirus occurs independently of natural killer cells.

Research paper by Sherry C SC Wen, Sharon J SJ Tollefson, Monika M Johnson, Pavlo P Gilchuk, Kelli L KL Boyd, Bryan B Shepherd, Sebastian S Joyce, John V JV Williams

Indexed on: 27 Jun '14Published on: 27 Jun '14Published in: Journal of virology



Abstract

Human metapneumovirus (HMPV) is a major cause of respiratory disease. The role of NK cells in protection against HMPV is unclear. We show that while HMPV-infected C57BL/6 mice had higher numbers of functional lung NK cells than mock-treated mice, comparing NK cell-depleted and control mice did not reveal differences in lung viral titers, histopathology, cytokine levels, or T cell numbers or function. These data indicate that NK cells are not required for host control of HMPV.