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A visible-light-induced cascade reaction of etherification/C-C cyclization: efficient synthesis of dibenzo[b,d]oxepin-7(6H)-ones.

Research paper by Wanyong W Fu, Aixia A Yu, Hongshuo H Jiang, Minghui M Zuo, Hongfeng H Wu, Zhongwen Z Yang, Qi Q An, Zhizhong Z Sun, Wenyi W Chu

Indexed on: 15 Apr '19Published on: 16 Mar '19Published in: Organic & Biomolecular Chemistry



Abstract

A visible-light-induced palladium-catalyzed cascade reaction was developed by etherification/C-C coupling cyclization of α-bromoacetophenones with phenols. A series of dibenzo[b,d]oxepin-7(6H)-one derivatives were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of protosappanin A. The protocol has advantages such as simple reaction conditions, wide range of substrates and high reaction efficiency.