A versatile route to C-6 arylmethyl-functionalized S-DABO and related analogues.

Research paper by Marco M Radi, Lorenzo L Contemori, Daniele D Castagnolo, Raffaella R Spinosa, José A JA Esté, Silvio S Massa, Maurizio M Botta

Indexed on: 13 Jul '07Published on: 13 Jul '07Published in: Organic Letters


Since their discovery in 1992, 3,4-dihydro-2-alkoxy-6-benzyl-4-oxypyrimidines (DABOs) have been subjected to many structural modifications in order to obtain better non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of AIDS. Herein, we report a straightforward and versatile route for the synthesis of novel C-6 arylmethyl-functionalized S-DABO, a poorly explored class of derivatives. Finally, biological evaluation of the synthesized derivatives led to the identification of a promising anti-HIV-1 lead compound.