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A transgenic monkey model for the study of human brain evolution.

Research paper by Lei L Shi, Bing B Su

Indexed on: 20 Aug '19Published on: 24 Apr '19Published in: Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji



Abstract

Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, ) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.