A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses.

Research paper by Jing J Huang, Xiaodong X Li, Tao T Qiao, Robert A RA Bambara, Russell R Hilf, Mesut M Muyan

Indexed on: 25 Jul '06Published on: 25 Jul '06Published in: Nuclear receptor signaling


The interaction of ERalpha and ERbeta with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERbeta is a weaker transactivator than E2-ERalpha. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional responses.