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A T-dependent plasma cell response: Part of a graft-versus-host and host-versus-graft reaction in the rabbit spleen

Research paper by J. E. Veldman, P. Nieuwenhuis, F. J. Keuning

Indexed on: 01 Dec '80Published on: 01 Dec '80Published in: Virchows Archiv. B, Cell pathology including molecular pathology



Abstract

B-cell reactivity, as expressed in a plasma cell reaction may be part of a graft-versus-host or host-versus-graft reaction. Cell transfer experiments were able to prove this. Histological evidence is presented for the occurrence of the so-called “allogeneic effect” during a graft-versus-host or host-versus-graft reaction in the rabbit spleen. Cell suspensions containing both T-and B-cells give rise to a cellular and a humoral immunity reaction component upon transfer to histoincompatible recipients. This can also occur during a graft-versus-host reaction. This B-cell response is T-cell dependent.