A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.

Imported: 10 Jan '17 | Published: 10 Jan '17

Di D Mao, Shin S Ando, Shin-Ichi SI Sato, Ying Y Qin, Nao N Hirata, Yousuke Y Katsuda, Eihachiro E Kawase, Ting-Fang TF Kuo, Itsunari I Minami, Yuji Y Shiba, Kazumitsu K Ueda, Norio N Nakatsuji, Motonari M Uesugi

Angewandte Chemie International Edition

Abstract: A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid molecules that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures. The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chemical probe for hiPSCs, and clinically used anticancer drugs. Among the... Read More

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