A Stereoselective Arylative-Cyclopropanation Process.

Research paper by Siomenan S Coulibali, Elsa E Deruer, Elizabeth E Godin, Sylvain S Canesi

Indexed on: 17 Feb '17Published on: 17 Feb '17Published in: Organic Letters


A new stereoselective arylative cyclopropanation process involving treatment of halogenated dienone systems in the presence of a Michael donor containing a nitro-aryl-sulfone has been developed. This transformation enables production of an arylated cyclopropane under mild conditions and occurs via a Michael-Smiles ring closure cascade process, reflecting the concepts of green chemistry and atom economy.