Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Immunity
In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis. Copyright © 2018 Elsevier Inc. All rights reserved.