A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations.

Research paper by Muhammad M Ayaz, Justin J Dietrich, Christopher C Hulme

Indexed on: 12 Oct '11Published on: 12 Oct '11Published in: Tetrahedron Letters


This communication reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.