A Novel Genetic Group of Bovine Hepacivirus in Archival Serum Samples from Brazilian Cattle.

Research paper by Cláudio W CW Canal, Matheus N MN Weber, Samuel P SP Cibulski, Mariana S MS Silva, Daniela E DE Puhl, Hanspeter H Stalder, Ernst E Peterhans

Indexed on: 15 Sep '17Published on: 15 Sep '17Published in: BioMed research international


Hepatitis C virus (HCV) (genus Hepacivirus; family Flaviviridae) is a major human pathogen causing persistent infection and hepatic injury. Recently, emerging HCV-like viruses were described infecting wild animals, such as bats and rodents, and domestic animals, including dogs, horses, and cattle. Using degenerate primers for detecting bovine pestiviruses in a 1996 survey three bovine serum samples showed a low identity with the genus Pestivirus of the Flaviviridae family. A virus could not be isolated in cell culture. The description of bovine hepaciviruses (BovHepV) in 2015 allowed us to retrospectively identify the sequences as BovHepV, with a 88.9% nucleotide identity. In a reconstructed phylogenetic tree, the Brazilian BovHepV samples grouped within the bovine HCV-like cluster in a separated terminal node that was more closely related to the putative bovine Hepacivirus common ancestor than to bovine hepaciviruses detected in Europe and Africa.