A new twist on the PYRIN Mediterranean coast.

Research paper by Luigi L Franchi, Gabriel G Núñez

Indexed on: 28 May '11Published on: 28 May '11Published in: Immunity


Familial Mediterranean fever is caused by mutations of the PYRIN protein. Chae et al. (2011) provide evidence for a ASC protein-dependent pathway of caspase-1 activation in which gain-of-function PYRIN mutations lead to IL-1β cytokine overproduction and inflammatory disease.