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A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA.

Research paper by Ivan I Vucković, Vlatka V Vajs, Miroslava M Stanković, Vele V Tesević, Slobodan S Milosavljević

Indexed on: 17 Mar '10Published on: 17 Mar '10Published in: Chemistry & Biodiversity



Abstract

A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, 1D- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.