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A Model for the Propagation of Action Potentials in Non-Uniformly Excitable Media.

Research paper by A Rabinovitch, I Aviram, N Gulko, E Ovsyshcher

Indexed on: 02 Mar '99Published on: 02 Mar '99Published in: Journal of Theoretical Biology



Abstract

Electrophysiological properties of cardiac tissue change as a function of position. We define the "excitability" as the propagation velocity of an excitation pulse through the tissue, and study a simple FitzHugh-Nagumo (FHN) model of heart tissue whose excitability changes with position. The propagation velocity is shown to be a good continuous measure of the excitability for both limit cycle and excitable tissue. The influence of the spatial dependence of the excitability is examined for several normal and pathological situations. A novel transient effect is observed for a train of pulses propagating across an excitability step. Copyright 1999 Academic Press.