A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase

Research paper by S. Ito, G. Prota

Indexed on: 01 Aug '77Published on: 01 Aug '77Published in: Cellular and Molecular Life Sciences


A convenient one-step procedure, based upon the tyrosinase co-oxidation of dopa and cysteine, is reported for the synthesis of 5-S-cysteinyldopa (I) in 74% yield. Secondary products of the reaction turned out to be 2-S-cysteinyldopa (II, 14%), 2,5-S, S-dicysteinyldopa (IV, 5%), and the hitherto unknown 6-S-cysteinyldopa (III, ∼1%).