A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues.

Research paper by Sanghye S Shin, Yechan Y Kim, Kiho K Kim, Sungwoo S Hong

Indexed on: 27 Jun '14Published on: 27 Jun '14Published in: Organic & Biomolecular Chemistry


An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C-H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone and chromone derivatives, which are prominent structural motifs in many biologically active compounds.