A convenient synthesis and structural analysis of novel 4,5,6,7-tetrahydro-1H-indazoles

Research paper by K. Murugavel, S. Amirthaganesan, R. T. Sabapathy Mohan

Indexed on: 03 Jul '10Published on: 03 Jul '10Published in: Chemistry of Heterocyclic Compounds


A new series of t-4-aryl-3,c-6-dihydroxy-6-methyl-4,5,6,7-tetrahydro-1H-indazole-r-5-carboxylic acid isopropyl esters has been synthesized by adopting a conventional method from cyclic β-keto esters. 1H, 13C NMR, and IR spectra for all the compounds were investigated. HMBC, HSQC, COSY, and NOESY spectra of the representative compounds were studied. The stereochemistry of a six-membered ring of the fused indazoles resembled that of keto esters. From the HMBC correlations the indazole structure was confirmed as 1H-indazole.