A convenient strategy for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles: oxidative dimerization of arylthioamides using CC–DMSO in PEG-400

Research paper by Ahmad Reza Khosropour, Jalil Noei

Indexed on: 16 Apr '10Published on: 16 Apr '10Published in: Monatshefte für Chemie - Chemical Monthly


An inexpensive and effective preparative protocol for the highly efficient synthesis of structurally diverse 3,5-diaryl-1,2,4-thiadiazoles at ambient temperature with 2,4,6-trichloro-1,3,5-triazine (CC) and DMSO in polyethylene glycol 400 (PEG-400) as solvent is described.

Graphical abstract 10.1007/s00706-010-0295-3.gif