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A case of serous cystadenoma of the pancreas with focal malignant changes.

Research paper by T T Ohta, T T Nagakawa, H H Itoh, L L Fonseca, I I Miyazaki, T T Terada

Indexed on: 01 Dec '93Published on: 01 Dec '93Published in: International journal of pancreatology : official journal of the International Association of Pancreatology



Abstract

We present a serous cystadenoma of the pancreas with focal malignant changes, and describe its characteristic histological features. On gross examination, a tumor was present on the anterior surface of the body of the pancreas and measured approx 25 x 25 x 20 mm. Microscopically, most tumor cells showed the typical histological features of serous cystadenoma, characterized by a microcystic architecture and glycogen-rich cells with a uniform and bland appearance. However, in some areas, a tendency to papillary structures with fibrovascular cores was noted. These papillary lesions were composed mainly of nonmucinous, glycogen-poor epithelial cells, the nuclei of which showed a mild atypia. In addition, vascular and perivascular invasion was focally observed. However, there was no clinical evidence of local or distant metastasis. From these findings, we diagnosed this lesion as a serous cystadenoma of the pancreas with focal malignant changes rather than a serous cystadenocarcinoma of the pancreas.