813 Metabolic products of Cutibacterium acnes protect against cutaneous biofilm formation by Staphylococci

Research paper by K. Nakamura, A. ONeill, M. Williams, L. Cau, T. Nakatsuji, R.L. Gallo

Indexed on: 17 Jun '20Published on: 01 Jul '20Published in: Journal of Investigative Dermatology


Bacterial biofilms are a major factor in delayed wound healing. Many staphylococcal species can form biofilms that have the potential to harm the host. DNA sequencing and qPCR of 16S RNA from bacteria isolated from human hair follicles by laser capture microdissection has shown that Staphylococci are highly abundant in the normal human follicles and co-exist with C. acnes. However, despite the high density of Staphylococci in follicles, biofilms seldom occur on healthy skin. We hypothesized that interactions between species in the commensal skin microbiome may regulate biofilm formation.