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8-Aza-7-deaza-2'-deoxy-2-(methylsulfanyl)adenosine.

Research paper by Frank F Seela, Anup M AM Jawalekar, Simone S Budow, Henning H Eickmeier

Indexed on: 07 Sep '05Published on: 07 Sep '05Published in: Acta crystallographica. Section C, Crystal structure communications



Abstract

In the title compound, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine, C11H16N5O3S, the conformation of the glycosidic bond is between anti and high anti. The 2'-deoxyribofuranosyl moiety adopts the C3'-exo-C4'-endo conformation (3T4, S-type sugar pucker), and the conformation at the exocyclic C-C bond is +sc (+gauche). The exocyclic 6-amine group and the 2-methylsulfanyl group lie on different sides of the heterocyclic ring system. The molecules form a three-dimensional hydrogen-bonded network that is stabilized by O-H...N, N-H...O and C-H...O hydrogen bonds.