327 Severe acne and biofilm production of Cutibacterium acnes strains: Different biofilm potentials for different phylotypes

Research paper by M. Dagnelie, M. Saint-Jean, A. Khammari, S. Corvec, B. Dréno

Indexed on: 24 Oct '20Published on: 01 Sep '19Published in: Journal of Investigative Dermatology


Acne is a chronic inflammatory dermatosis in which Cutibacterium acnes plays a crucial role. C. acnes population is subdivided into 6 distinct phylotypes: IA1, IA2, IB, IC, II and III. Recently, finer methods to discriminate subpopulations within C. acnes phylotypes highlighted the predominance of SLST-types A1, A5 and D1 in Severe Acne (SA) context. The objective was to determine whether the ability to establish a biofilm varied according to the different subtypes of C. acnes clinical strains characterized and implicated in SA.