3-allylation of tert-butyl 4-oxopiperidine-1-carboxylate

Research paper by A. I. Moskalenko, V. I. Boev

Indexed on: 17 Dec '14Published on: 17 Dec '14Published in: Russian Journal of Organic Chemistry


Reaction of tert-butyl 4-oxopiperidine-1-carboxylate dimethylhydrazone with BuLi in the presence of N,N’-dimethylpropylene urea and subsequently with BrCH2CH=CRR’ (R=H, Me, Et; R’=CH2Ar) afforded in 50–80% yields the corresponding tert-butyl 3-alkenyl-4-oxopiperidine-1-carboxylates, promising synthons for preparation of diverse piperidine derivatives.