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1,3-Dimethyl-3-silapiperidine: synthesis, molecular structure, and conformational analysis by gas-phase electron diffraction, low temperature NMR, IR and Raman spectroscopy, and quantum chemical calculations.

Research paper by Bagrat A BA Shainyan, Svetlana V SV Kirpichenko, Erich E Kleinpeter, Sergey A SA Shlykov, Dmitriy Yu DY Osadchiy, Nina N NN Chipanina, Larisa P LP Oznobikhina

Indexed on: 13 Mar '13Published on: 13 Mar '13Published in: Journal of Organic Chemistry



Abstract

The first Si-H-containing azasilaheterocycle, 1,3-dimethyl-3-silapiperidine 1, was synthesized, and its molecular structure and conformational properties were studied by gas-phase electron diffraction (GED), low temperature NMR, IR and Raman spectroscopy and quantum chemical calculations. The compound exists as a mixture of two conformers possessing the chair conformation with the equatorial NMe group and differing by axial or equatorial position of the SiMe group. In the gas phase, the SiMe(ax) conformer predominates (GED: ax/eq = 65(7):35(7)%, ΔG = 0.36(18) kcal/mol; IR: ax/eq = 62(5):38(5)%, ΔG = 0.16(7) kcal/mol). In solution, at 143 K the SiMe(eq) conformer predominates in the frozen equilibrium (NMR: ax/eq = 31.5(1.5):68.5(1.5)%, ΔG = -0.22(2) kcal/mol). Thermodynamic parameters of the ring inversion are determined (ΔG(‡) = 8.9-9.0 kcal/mol, ΔH(‡) = 9.6 kcal/mol, ΔS(‡) = 2.1 eu). High-level quantum chemical calculations (MP2, G2, CCSD(T)) nicely reproduce the experimental geometry and the predominance of the axial conformer in the gas phase.