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041 miR-146a regulates the interleukin-17 inflammatory response to Cutibacterium acnes in human peripheral blood mononuclear cells

Research paper by A.T. Pham, M. Qin, T. To, A. Baugh, J. Kim

Indexed on: 17 Jun '20Published on: 01 Jul '20Published in: Journal of Investigative Dermatology



Abstract

Inflammation from the immune response targeting Cutibacterium acnes plays a significant role in the pathogenesis of acne vulgaris. Previous studies have shown that C. acnes is a potent inducer of T helper 17 (Th17) cells, a unique class of CD4+ T cells characterized by production of the highly inflammatory cytokine interleukin-17 (IL-17). Emerging evidence has shown that microRNAs (miRNAs) play an important role in modulating the body’s inflammatory response, including regulation of Th17 differentiation and IL-17 production.